Amitriptyline, dem sell under de brand name Elavil among odas, be a tricyclic antidepressant dem primarily use to treat major depressive disorder, den a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine den tension headaches. Secof de frequency den prominence of side effects, amitriptyline be generally considered a second-line therapy for dese indications.
De most common side effects be dry mouth, drowsiness, dizziness, constipation, den weight gain. Glaucoma, liver toxicity den abnormal heart rhythms be rare buh serious side effects. Blood levels of amitriptyline de vary significantly from one person to anoda, den amitriptyline interacts plus chaw oda medications potentially dey aggravate ein side effects.
Na dem discover amitriptyline insyd de late 1950s by scientists at Merck wey dem approve by de US Food and Drug Administration (FDA) insyd 1961. E dey on de World Health Organization's List of Essential Medicines. E be available as a generic medication. Insyd 2023, na e be de 90th most commonly prescribed medication insyd de United States, plus more dan 7 million prescriptions.
Read further
- Dean L (March 2017). "Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, Scott SA, Dean LC, Kattman BL, et al. (eds.). Medical Genetics Summaries. National Center for Biotechnology Information (NCBI). PMID 28520380.
