Protein-coding gene in the species Homo sapiens

PTPN3

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Aliases: PTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
External IDs: OMIM: 176877; MGI: 105307; GeneCards: PTPN3
PDB: Ortholog search: PDBe RCSB
3.1.3.48: ↗
Chr.: Chromosome 9 (human)
Band: 9q31.3
End: 109,498,313 bp
Chr.: Chromosome 4 (mouse)
Band: 4 B3|4 31.66 cM
End: 57,301,837 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 5774
Ensembl: ENSG00000070159
UniProt: P26045
RefSeq (mRNA): NM_001145368NM_001145369NM_001145370NM_001145371NM_001145372NM_002829
RefSeq (protein): NP_001138840NP_001138841NP_001138842NP_001138843NP_001138844NP_002820
Location (UCSC): Chr 9: 109.38 – 109.5 Mb

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.