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Protein-coding gene in the species Homo sapiens

YWHAB

YWHAB
All data from the card 18
Aliases
YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
External IDs
OMIM: 601289; MGI: 1891917; GeneCards: YWHAB
PDB
Ortholog search: PDBe RCSB
Chr.
Chromosome 20 (human)
Band
20q13.12
End
44,908,532 bp
Chr.
Chromosome 2 (mouse)
Band
2|2 H3
End
163,860,508 bp
BioGPS
More reference expression data
Databases
NCBI: entry; OMA: entry
Species
Human
Entrez
7529
Ensembl
ENSG00000166913
UniProt
P31946Q4VY19
RefSeq (mRNA)
NM_139323NM_003404
RefSeq (protein)
NP_003395NP_647539
Location (UCSC)
Chr 20: 44.89 – 44.91 Mb

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

Function

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.

Interactions

YWHAB has been shown to interact with:

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Text from Wikipedia, CC BY-SA 4.0 · Source article