Protein-coding gene in humans

LPAR3

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Aliases: LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs: OMIM: 605106; MGI: 1929469; GeneCards: LPAR3
Chr.: Chromosome 1 (human)
Band: 1p22.3
End: 84,893,206 bp
Chr.: Chromosome 3 (mouse)
Band: 3 H2|3 71.03 cM
End: 145,991,941 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 23566
Ensembl: ENSG00000171517
UniProt: Q9UBY5
RefSeq (mRNA): NM_012152
RefSeq (protein): NP_036284
Location (UCSC): Chr 1: 84.81 – 84.89 Mb

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein in humans that is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.