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Protein-coding gene in the species Homo sapiens

GPR6

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GPR6

All data from the card 17

Aliases: GPR6, G protein-coupled receptor 6
External IDs: OMIM: 600553; MGI: 2155249; GeneCards: GPR6
Chr.: Chromosome 6 (human)
Band: 6q21
End: 109,980,720 bp
Chr.: Chromosome 10 (mouse)
Band: 10 B1|10 22.08 cM
End: 40,948,281 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 2830
Ensembl: ENSG00000146360
UniProt: P46095
RefSeq (mRNA): NM_005284NM_001286099
RefSeq (protein): NP_001273028NP_005275
Location (UCSC): Chr 6: 109.98 – 109.98 Mb

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active. It was previously thought to also act as a sphingosine-1-phosphate receptor, but this was found to not be the case in later research.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Ligand

Inverse Agonist

Cannabidiol
Solangepras (solengepras; CVN-424)

Evolution

Paralogues to GPR6 gene

Source:

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In 5 languages

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