Protein-coding gene in the species Homo sapiens

LPAR2

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Aliases: LPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs: OMIM: 605110; MGI: 1858422; GeneCards: LPAR2
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 19 (human)
Band: 19p13.11
End: 19,628,930 bp
Chr.: Chromosome 8 (mouse)
Band: 8 B3.3|8 33.91 cM
End: 70,283,752 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 9170
Ensembl: ENSG00000064547
UniProt: Q9HBW0
RefSeq (mRNA): NM_004720NM_001395660
RefSeq (protein): NP_004711
Location (UCSC): Chr 19: 19.62 – 19.63 Mb

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.