Cucurbitane

Natural compounds

Compounds with the basic cucurbitane skeleton are found in many plants, and some are important phytopharmaceuticals. Natural cucurbitane-related compounds include:

Named

• Balsaminapentaol, from Momordica balsamina.
• Balsaminol A, from Momordica balsamina.
• Balsaminol B, from Momordica balsamina.
• Brydioside A from Bryonia dioica
• Bryoamaride and derivatives from Bryonia dioica
• Charantin or foetidin, from Momordica charantia and Momordica foetida
• Charantosides I-VIII, from Momordica charantia.
• Cucurbalsaminol B, from Momordica balsamina.
• Cucurbalsaminol A, from Momordica balsamina.
• Cucurbitacins A-L, O-T
• Datiscosides, from Datisca glomerata
• Endecaphyllacins A and B, from roots of Hemsleya endecaphylla
• Hemslecins A and B, from roots of H. endecaphylla
• Lepidolide, from the mushroom Russula lepida
• Karavilagenin E, from Momordica balsamina.
• Khekadaengosides A, B, D and K, from Trichosanthes tricuspidata
• Kuguacins A-S, from stems and leaves of Momordica charantia
• Kuguaglycosides A-H, from the root of Momordica charantia
• Mogrosides I-V, from the fruits of Siraitia grosvenorii
• Momordicin I, II and 28, from Momordica charantia
• Momordicines II and IV, from leaves of Momordica charantia
• Momordicosides A-S, from Momordica charantia fruits
• Neokuguaglucoside, from Momordica charantia fruits
• Neomogroside, from the fruit of Siraitia grosvenorii.
• Pentanorcucurbitacins A and B
• Perseapicroside A, from Persea mexicana
• Scandenoside R9, from Hemsleya panacis-scandens
• Spinosides A and B, from Desfontainia spinosa

Unnamed

• 3β,7β,23ξ-trihydroxycucurbita-5,24-dien-19-al, soluble in chloroform, melts at 123−125 °C, from Momordica charantia, Momordica foetida.
• 3β,7β,25-trihydroxycucurbita-5,23-dien-19-al, soluble in chloroform, melts at 188−191 °C, from Momordica charantia, Momordica foetida
• 3β,7β-dihydroxy-25-methoxycucurbita-5,23-dien-19-al, soluble in chloroform, from Momordica charantia, Momordica foetida
• 5β,19-epoxy-25-methoxycucurbita-6,23-dien-3β,19-diol, soluble in chloroform, melts at 182−184 °C, from Momordica foetida
• 5β,19-epoxycucurbita-6,23-dien-3β,19,25-triol, soluble in chloroform, from Momordica foetida
• 5β,19-epoxy-19-methoxycucurbita-6,23-dien-3β,25-diol, soluble in chloroform, melts at 102−104 °C, from Momordica charantia, Momordica foetida
• 5β,19-epoxy-19,25-dimethoxycucurbita-6,23-dien-3β-ol, soluble in chloroform, from Momordica charantia, Momordica foetida
• 5β,19-epoxy-25-methoxycucurbita-6,23-dien-3β-ol, soluble in chloroform, melts at 139−141 °C, from Momordica charantia, Momordica foetida
• 19(R)-n-butanoxy-5β,19-epoxycucurbita-6,23-diene-3β,25-diol 3-O-β-glucopyranoside, C
  ₄₀H
  ₆₆O
  ₉, white powder soluble in methanol, from Momordica charantia fruit (8 mg/35 kg)
• 23-O-β-allopyranosylecucurbita-5,24-dien-7α,3β,22(R),23(S)-tetraol 3-O-β-allopyranoside,C
  ₄₂H
  ₆₉O
  ₁₄, white powder soluble in methanol, from Momordica charantia fruit (10 mg/35 kg)
• 23(R),24(S),25-trihydroxycucurbit-5-ene 3-O-{[β-glucopyranosyl(1→6)]-O-β-glucopyranosyl}-25-O-β-glucopyranoside, C
  ₄₈H
  ₈₂O
  ₁₉, white powder soluble in methanol, from Momordica charantia fruit (10 mg/35 kg)
• 2,16-dihydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 2-O-β-D-glucopyranoside, soluble in ethanol, from Cucurbita pepo fruits (25 mg/15 kg)
• 16-hydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside, white powder, soluble in ethanol, from Cucurbita pepo fruits (12 mg/15 kg)
• 7-methoxycucurbita-5,24-diene-3β,23(R)-diol, from Momordica balsamina
• 25,26,27-trinorcucurbit-5-ene-3,7,23-trione C
  ₂₇H
  ₄₀O
  ₃, white powder, soluble in methanol, from stems of Momordica charantia (6 mg/18 kg)