Protein-coding gene in humans

ARL1

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Aliases: ARL1, ARFL1, ADP ribosylation factor like GTPase 1
External IDs: OMIM: 603425; MGI: 99436; GeneCards: ARL1
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 12 (human)
Band: 12q23.2
End: 101,407,772 bp
Chr.: Chromosome 10 (mouse)
Band: 10|10 C1
End: 88,579,956 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 400
Ensembl: ENSG00000120805
UniProt: P40616
RefSeq (mRNA): NM_001301068NM_001177
RefSeq (protein): NP_001168NP_001287997
Location (UCSC): Chr 12: 101.39 – 101.41 Mb

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

Function

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.