Protein-coding gene in the species Homo sapiens

SF3B2

1 min read
In 3 languages

All data from the card 18

Aliases: SF3B2, Cus1, SAP145, SF3B145, SF3b1, SF3b150, splicing factor 3b subunit 2, CFM
External IDs: OMIM: 605591; MGI: 2441856; GeneCards: SF3B2
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 11 (human)
Band: 11q13.1
End: 66,069,308 bp
Chr.: Chromosome 19 (mouse)
Band: 19|19 A
End: 5,345,483 bp
BioGPS: n/a
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 10992
Ensembl: ENSG00000087365
UniProt: Q13435
RefSeq (mRNA): NM_006842
RefSeq (protein): NP_006833
Location (UCSC): Chr 11: 66.05 – 66.07 Mb

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

Function

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.