Function
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Interactions
CDC5L has been shown to interact with:
- ASF/SF2,
- BZW1,
- CWC15,
- DNA-PKcs,
- DYNC1H1,
- GCN1L1,
- HSPA8,
- ILF2,
- PLRG1,
- PPM1D,
- PPP1CA,
- PRPF19,
- RBMX and
- RPL12,
- RPL13,
- RPS16,
- RPS25,
- SF3A1,
- SF3B1,
- SF3B2,
- SF3B4,
- SFPQ,
- SRSF2,
- SNRPA1,
- SNRPD3,
- SRRM1,
- Small nuclear ribonucleoprotein D1,
- Small nuclear ribonucleoprotein D2,
- Small nuclear ribonucleoprotein polypeptide A,
- TOP2A, and
- TTF2.
