Protein-coding gene in the species Homo sapiens

RGS4

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Aliases: RGS4, Rgs4, AA004315, AA597169, ESTM48, ESTM50, RGP4, SCZD9, regulator of G-protein signaling 4, regulator of G protein signaling 4
External IDs: OMIM: 602516; MGI: 108409; GeneCards: RGS4
Chr.: Chromosome 1 (human)
Band: 1q23.3
End: 163,076,802 bp
Chr.: Chromosome 1 (mouse)
Band: 1 H2.3|1 76.84 cM
End: 169,575,211 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 5999
Ensembl: ENSG00000117152
UniProt: P49798
RefSeq (mRNA): NM_001102445NM_001113380NM_001113381NM_005613
RefSeq (protein): NP_001095915NP_001106851NP_001106852NP_005604NP_005604.1
Location (UCSC): Chr 1: 163.07 – 163.08 Mb

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.

Function

Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the G_i alpha, G_o alpha and G_q alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain which conveys GAP activity. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.

Clinical significance

A number of studies associate the RGS4 gene with schizophrenia, while some fail to detect an association.

RGS4 is also of interest as one of the three main RGS proteins (along with RGS9 and RGS17) involved in terminating signalling by the mu opioid receptor, and may be important in the development of tolerance to opioid drugs.