Protein-coding gene in humans

RBBP5

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Aliases: RBBP5, RBQ3, SWD1, retinoblastoma binding protein 5, RB binding protein 5, histone lysine methyltransferase complex subunit
External IDs: OMIM: 600697; MGI: 1918367; GeneCards: RBBP5
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 1 (human)
Band: 1q32.1
End: 205,122,015 bp
Chr.: Chromosome 1 (mouse)
Band: 1|1 E4
End: 132,433,397 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 5929
Ensembl: ENSG00000117222
UniProt: Q15291
RefSeq (mRNA): NM_001193272NM_001193273NM_005057
RefSeq (protein): NP_001180201NP_001180202NP_005048
Location (UCSC): Chr 1: 205.09 – 205.12 Mb

Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.