Protein-coding gene in the species Homo sapiens

FOSL1

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Aliases: FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDs: OMIM: 136515; MGI: 107179; GeneCards: FOSL1
Chr.: Chromosome 11 (human)
Band: 11q13.1
End: 65,900,573 bp
Chr.: Chromosome 19 (mouse)
Band: 19 A|19 4.33 cM
End: 5,505,974 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 8061
Ensembl: ENSG00000175592
UniProt: P15407
RefSeq (mRNA): NM_001300844NM_001300855NM_001300856NM_001300857NM_005438
RefSeq (protein): NP_001287773NP_001287784NP_001287785NP_001287786NP_005429
Location (UCSC): Chr 11: 65.89 – 65.9 Mb

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.