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PROC

PROC
All data from the card 13
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
PROC, APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa
Dynodwyr allanol
OMIM: 612283 HomoloGene: 37288 GeneCards: PROC
EC number
3.4.21.69
Gweithrediad moleciwlaidd
• calcium ion binding• GO:0070122 peptidase activity• GO:0001948, GO:0016582 protein binding• serine-type peptidase activity• serine-type endopeptidase activity• hydrolase activity
Cydrannau o'r gell
• Golgi apparatus• endoplasmic reticulum lumen• extracellular region• Reticwlwm endoplasmig• Golgi lumen• extracellular space
Species
Bod dynol
Entrez
5624
Ensembl
ENSG00000115718
UniProt
P04070
RefSeq (mRNA)
NM_000312
RefSeq (protein)
NP_000303NP_001362531NP_001362532NP_001362533NP_001362534NP_001362535NP_001362536NP_001362537NP_001362538NP_001362539NP_001362540NP_001362542
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn PROC yw PROC a elwir hefyd yn Protein C, inactivator of coagulation factors Va and VIIIa (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PROC.

  • PC
  • APC
  • PROC1
  • THPH3
  • THPH4

Llyfryddiaeth

  • "Activated protein C inhibits neutrophil extracellular trap formation in vitroand activation in vivo. ". J Biol Chem. 2017. PMID 28408624.
  • "[Analysis of phenotypes and genetic mutations in two pedigrees affected with hereditary protein C deficiency]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28186585.
  • "The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. ". Pediatr Blood Cancer. 2017. PMID 28111891.
  • "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities). ". Arterioscler Thromb Vasc Biol. 2017. PMID 28082259.
  • "Two novel compound heterozygous mutations associated with types I and II protein C deficiency with unusual phenotypes.". Thromb Res. 2016. PMID 27517348.

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