KMT2C (англ. Lysine methyltransferase 2C) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 7-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 911 амінокислот, а молекулярна маса — 541 370.
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
| MSSEEDKSVE | QPQPPPPPPE | EPGAPAPSPA | AADKRPRGRP | RKDGASPFQR | ||||
| ARKKPRSRGK | TAVEDEDSMD | GLETTETETI | VETEIKEQSA | EEDAEAEVDN | ||||
| SKQLIPTLQR | SVSEESANSL | VSVGVEAKIS | EQLCAFCYCG | EKSSLGQGDL | ||||
| KQFRITPGFI | LPWRNQPSNK | KDIDDNSNGT | YEKMQNSAPR | KQRGQRKERS | ||||
| PQQNIVSCVS | VSTQTASDDQ | AGKLWDELSL | VGLPDAIDIQ | ALFDSTGTCW | ||||
| AHHRCVEWSL | GVCQMEEPLL | VNVDKAVVSG | STERCAFCKH | LGATIKCCEE | ||||
| KCTQMYHYPC | AAGAGTFQDF | SHIFLLCPEH | IDQAPERSKE | DANCAVCDSP | ||||
| GDLLDQFFCT | TCGQHYHGMC | LDIAVTPLKR | AGWQCPECKV | CQNCKQSGED | ||||
| SKMLVCDTCD | KGYHTFCLQP | VMKSVPTNGW | KCKNCRICIE | CGTRSSSQWH | ||||
| HNCLICDNCY | QQQDNLCPFC | GKCYHPELQK | DMLHCNMCKR | WVHLECDKPT | ||||
| DHELDTQLKE | EYICMYCKHL | GAEMDRLQPG | EEVEIAELTT | DYNNEMEVEG | ||||
| PEDQMVFSEQ | AANKDVNGQE | STPGIVPDAV | QVHTEEQQKS | HPSESLDTDS | ||||
| LLIAVSSQHT | VNTELEKQIS | NEVDSEDLKM | SSEVKHICGE | DQIEDKMEVT | ||||
| ENIEVVTHQI | TVQQEQLQLL | EEPETVVSRE | ESRPPKLVME | SVTLPLETLV | ||||
| SPHEESISLC | PEEQLVIERL | QGEKEQKENS | ELSTGLMDSE | MTPTIEGCVK | ||||
| DVSYQGGKSI | KLSSETESSF | SSSADISKAD | VSSSPTPSSD | LPSHDMLHNY | ||||
| PSALSSSAGN | IMPTTYISVT | PKIGMGKPAI | TKRKFSPGRP | RSKQGAWSTH | ||||
| NTVSPPSWSP | DISEGREIFK | PRQLPGSAIW | SIKVGRGSGF | PGKRRPRGAG | ||||
| LSGRGGRGRS | KLKSGIGAVV | LPGVSTADIS | SNKDDEENSM | HNTVVLFSSS | ||||
| DKFTLNQDMC | VVCGSFGQGA | EGRLLACSQC | GQCYHPYCVS | IKITKVVLSK | ||||
| GWRCLECTVC | EACGKATDPG | RLLLCDDCDI | SYHTYCLDPP | LQTVPKGGWK | ||||
| CKWCVWCRHC | GATSAGLRCE | WQNNYTQCAP | CASLSSCPVC | YRNYREEDLI | ||||
| LQCRQCDRWM | HAVCQNLNTE | EEVENVADIG | FDCSMCRPYM | PASNVPSSDC | ||||
| CESSLVAQIV | TKVKELDPPK | TYTQDGVCLT | ESGMTQLQSL | TVTVPRRKRS | ||||
| KPKLKLKIIN | QNSVAVLQTP | PDIQSEHSRD | GEMDDSREGE | LMDCDGKSES | ||||
| SPEREAVDDE | TKGVEGTDGV | KKRKRKPYRP | GIGGFMVRQR | SRTGQGKTKR | ||||
| SVIRKDSSGS | ISEQLPCRDD | GWSEQLPDTL | VDESVSVTES | TEKIKKRYRK | ||||
| RKNKLEETFP | AYLQEAFFGK | DLLDTSRQSK | ISLDNLSEDG | AQLLYKTNMN | ||||
| TGFLDPSLDP | LLSSSSAPTK | SGTHGPADDP | LADISEVLNT | DDDILGIISD | ||||
| DLAKSVDHSD | IGPVTDDPSS | LPQPNVNQSS | RPLSEEQLDG | ILSPELDKMV | ||||
| TDGAILGKLY | KIPELGGKDV | EDLFTAVLSP | ANTQPTPLPQ | PPPPTQLLPI | ||||
| HNQDAFSRMP | LMNGLIGSSP | HLPHNSLPPG | SGLGTFSAIA | QSSYPDARDK | ||||
| NSAFNPMASD | PNNSWTSSAP | TVEGENDTMS | NAQRSTLKWE | KEEALGEMAT | ||||
| VAPVLYTNIN | FPNLKEEFPD | WTTRVKQIAK | LWRKASSQER | APYVQKARDN | ||||
| RAALRINKVQ | MSNDSMKRQQ | QQDSIDPSSR | IDSELFKDPL | KQRESEHEQE | ||||
| WKFRQQMRQK | SKQQAKIEAT | QKLEQVKNEQ | QQQQQQQFGS | QHLLVQSGSD | ||||
| TPSSGIQSPL | TPQPGNGNMS | PAQSFHKELF | TKQPPSTPTS | TSSDDVFVKP | ||||
| QAPPPPPAPS | RIPIQDSLSQ | AQTSQPPSPQ | VFSPGSSNSR | PPSPMDPYAK | ||||
| MVGTPRPPPV | GHSFSRRNSA | APVENCTPLS | SVSRPLQMNE | TTANRPSPVR | ||||
| DLCSSSTTNN | DPYAKPPDTP | RPVMTDQFPK | SLGLSRSPVV | SEQTAKGPIA | ||||
| AGTSDHFTKP | SPRADVFQRQ | RIPDSYARPL | LTPAPLDSGP | GPFKTPMQPP | ||||
| PSSQDPYGSV | SQASRRLSVD | PYERPALTPR | PIDNFSHNQS | NDPYSQPPLT | ||||
| PHPAVNESFA | HPSRAFSQPG | TISRPTSQDP | YSQPPGTPRP | VVDSYSQSSG | ||||
| TARSNTDPYS | QPPGTPRPTT | VDPYSQQPQT | PRPSTQTDLF | VTPVTNQRHS | ||||
| DPYAHPPGTP | RPGISVPYSQ | PPATPRPRIS | EGFTRSSMTR | PVLMPNQDPF | ||||
| LQAAQNRGPA | LPGPLVRPPD | TCSQTPRPPG | PGLSDTFSRV | SPSAARDPYD | ||||
| QSPMTPRSQS | DSFGTSQTAH | DVADQPRPGS | EGSFCASSNS | PMHSQGQQFS | ||||
| GVSQLPGPVP | TSGVTDTQNT | VNMAQADTEK | LRQRQKLREI | ILQQQQQKKI | ||||
| AGRQEKGSQD | SPAVPHPGPL | QHWQPENVNQ | AFTRPPPPYP | GNIRSPVAPP | ||||
| LGPRYAVFPK | DQRGPYPPDV | ASMGMRPHGF | RFGFPGGSHG | TMPSQERFLV | ||||
| PPQQIQGSGV | SPQLRRSVSV | DMPRPLNNSQ | MNNPVGLPQH | FSPQSLPVQQ | ||||
| HNILGQAYIE | LRHRAPDGRQ | RLPFSAPPGS | VVEASSNLRH | GNFIPRPDFP | ||||
| GPRHTDPMRR | PPQGLPNQLP | VHPDLEQVPP | SQQEQGHSVH | SSSMVMRTLN | ||||
| HPLGGEFSEA | PLSTSVPSET | TSDNLQITTQ | PSDGLEEKLD | SDDPSVKELD | ||||
| VKDLEGVEVK | DLDDEDLENL | NLDTEDGKVV | ELDTLDNLET | NDPNLDDLLR | ||||
| SGEFDIIAYT | DPELDMGDKK | SMFNEELDLP | IDDKLDNQCV | SVEPKKKEQE | ||||
| NKTLVLSDKH | SPQKKSTVTN | EVKTEVLSPN | SKVESKCETE | KNDENKDNVD | ||||
| TPCSQASAHS | DLNDGEKTSL | HPCDPDLFEK | RTNRETAGPS | ANVIQASTQL | ||||
| PAQDVINSCG | ITGSTPVLSS | LLANEKSDNS | DIRPSGSPPP | PTLPASPSNH | ||||
| VSSLPPFIAP | PGRVLDNAMN | SNVTVVSRVN | HVFSQGVQVN | PGLIPGQSTV | ||||
| NHSLGTGKPA | TQTGPQTSQS | GTSSMSGPQQ | LMIPQTLAQQ | NRERPLLLEE | ||||
| QPLLLQDLLD | QERQEQQQQR | QMQAMIRQRS | EPFFPNIDFD | AITDPIMKAK | ||||
| MVALKGINKV | MAQNNLGMPP | MVMSRFPFMG | QVVTGTQNSE | GQNLGPQAIP | ||||
| QDGSITHQIS | RPNPPNFGPG | FVNDSQRKQY | EEWLQETQQL | LQMQQKYLEE | ||||
| QIGAHRKSKK | ALSAKQRTAK | KAGREFPEED | AEQLKHVTEQ | QSMVQKQLEQ | ||||
| IRKQQKEHAE | LIEDYRIKQQ | QQCAMAPPTM | MPSVQPQPPL | IPGATPPTMS | ||||
| QPTFPMVPQQ | LQHQQHTTVI | SGHTSPVRMP | SLPGWQPNSA | PAHLPLNPPR | ||||
| IQPPIAQLPI | KTCTPAPGTV | SNANPQSGPP | PRVEFDDNNP | FSESFQERER | ||||
| KERLREQQER | QRIQLMQEVD | RQRALQQRME | MEQHGMVGSE | ISSSRTSVSQ | ||||
| IPFYSSDLPC | DFMQPLGPLQ | QSPQHQQQMG | QVLQQQNIQQ | GSINSPSTQT | ||||
| FMQTNERRQV | GPPSFVPDSP | SIPVGSPNFS | SVKQGHGNLS | GTSFQQSPVR | ||||
| PSFTPALPAA | PPVANSSLPC | GQDSTITHGH | SYPGSTQSLI | QLYSDIIPEE | ||||
| KGKKKRTRKK | KRDDDAESTK | APSTPHSDIT | APPTPGISET | TSTPAVSTPS | ||||
| ELPQQADQES | VEPVGPSTPN | MAAGQLCTEL | ENKLPNSDFS | QATPNQQTYA | ||||
| NSEVDKLSME | TPAKTEEIKL | EKAETESCPG | QEEPKLEEQN | GSKVEGNAVA | ||||
| CPVSSAQSPP | HSAGAPAAKG | DSGNELLKHL | LKNKKSSSLL | NQKPEGSICS | ||||
| EDDCTKDNKL | VEKQNPAEGL | QTLGAQMQGG | FGCGNQLPKT | DGGSETKKQR | ||||
| SKRTQRTGEK | AAPRSKKRKK | DEEEKQAMYS | STDTFTHLKQ | QNNLSNPPTP | ||||
| PASLPPTPPP | MACQKMANGF | ATTEELAGKA | GVLVSHEVTK | TLGPKPFQLP | ||||
| FRPQDDLLAR | ALAQGPKTVD | VPASLPTPPH | NNQEELRIQD | HCGDRDTPDS | ||||
| FVPSSSPESV | VGVEVSRYPD | LSLVKEEPPE | PVPSPIIPIL | PSTAGKSSES | ||||
| RRNDIKTEPG | TLYFASPFGP | SPNGPRSGLI | SVAITLHPTA | AENISSVVAA | ||||
| FSDLLHVRIP | NSYEVSSAPD | VPSMGLVSSH | RINPGLEYRQ | HLLLRGPPPG | ||||
| SANPPRLVSS | YRLKQPNVPF | PPTSNGLSGY | KDSSHGIAES | AALRPQWCCH | ||||
| CKVVILGSGV | RKSFKDLTLL | NKDSRESTKR | VEKDIVFCSN | NCFILYSSTA | ||||
| QAKNSENKES | IPSLPQSPMR | ETPSKAFHQY | SNNISTLDVH | CLPQLPEKAS | ||||
| PPASPPIAFP | PAFEAAQVEA | KPDELKVTVK | LKPRLRAVHG | GFEDCRPLNK | ||||
| KWRGMKWKKW | SIHIVIPKGT | FKPPCEDEID | EFLKKLGTSL | KPDPVPKDYR | ||||
| KCCFCHEEGD | GLTDGPARLL | NLDLDLWVHL | NCALWSTEVY | ETQAGALINV | ||||
| ELALRRGLQM | KCVFCHKTGA | TSGCHRFRCT | NIYHFTCAIK | AQCMFFKDKT | ||||
| MLCPMHKPKG | IHEQELSYFA | VFRRVYVQRD | EVRQIASIVQ | RGERDHTFRV | ||||
| GSLIFHTIGQ | LLPQQMQAFH | SPKALFPVGY | EASRLYWSTR | YANRRCRYLC | ||||
| SIEEKDGRPV | FVIRIVEQGH | EDLVLSDISP | KGVWDKILEP | VACVRKKSEM | ||||
| LQLFPAYLKG | EDLFGLTVSA | VARIAESLPG | VEACENYTFR | YGRNPLMELP | ||||
| LAVNPTGCAR | SEPKMSAHVK | RFVLRPHTLN | STSTSKSFQS | TVTGELNAPY | ||||
| SKQFVHSKSS | QYRKMKTEWK | SNVYLARSRI | QGLGLYAARD | IEKHTMVIEY | ||||
| IGTIIRNEVA | NRKEKLYESQ | NRGVYMFRMD | NDHVIDATLT | GGPARYINHS | ||||
| CAPNCVAEVV | TFERGHKIII | SSSRRIQKGE | ELCYDYKFDF | EDDQHKIPCH | ||||
| CGAVNCRKWM | N |
Кодований геном білок за функціями належить до трансфераз, активаторів, ацилтрансфераз, регуляторів хроматину, метилтрансфераз, фосфопротеїнів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК, S-аденозил-L-метіоніном. Локалізований у ядрі.
