Protein-coding gene in the species Homo sapiens

TSC22D3

1 min read
In 4 languages

All data from the card 17

Aliases: TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP, TSC22 domain family member 3
External IDs: OMIM: 300506; MGI: 1196284; GeneCards: TSC22D3
Chr.: X chromosome (human)
Band: Xq22.3
End: 107,777,342 bp
Chr.: X chromosome (mouse)
Band: X|X F1
End: 139,501,408 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 1831
Ensembl: ENSG00000157514
UniProt: Q99576
RefSeq (mRNA): NM_001015881NM_004089NM_198057NM_001318468NM_001318470
RefSeq (protein): NP_001015881NP_001305397NP_001305399NP_004080NP_932174
Location (UCSC): Chr X: 107.71 – 107.78 Mb

TSC22 domain family protein 3 is a protein that in humans is encoded by the TSC22D3 gene.

Function

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. GILZ shows ubiquitous expression across tissues, including thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.