Protein-coding gene in the species Homo sapiens

TRAF3

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All data from the card 19

Aliases: TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
External IDs: OMIM: 601896; MGI: 108041; GeneCards: TRAF3
PDB: Ortholog search: PDBe RCSB
2.3.2.27: ↗
Chr.: Chromosome 14 (human)
Band: 14q32.32
End: 102,911,500 bp
Chr.: Chromosome 12 (mouse)
Band: 12 F1|12 60.94 cM
End: 111,233,587 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 7187
Ensembl: ENSG00000131323
UniProt: Q13114
RefSeq (mRNA): NM_001199427NM_003300NM_145725NM_145726NM_001385142NM_001385143
RefSeq (protein): NP_001186356NP_003291NP_663777NP_663778
Location (UCSC): Chr 14: 102.78 – 102.91 Mb

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene.

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus-encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.