Protein-coding gene in the species Homo sapiens

SNRPB

1 min read
In 6 languages

All data from the card 18

Aliases: SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
External IDs: OMIM: 182282; MGI: 98342; GeneCards: SNRPB
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 20 (human)
Band: 20p13
End: 2,470,853 bp
Chr.: Chromosome 2 (mouse)
Band: 2 F1|2 63.19 cM
End: 130,021,323 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 6628
Ensembl: ENSG00000125835
UniProt: P14678
RefSeq (mRNA): NM_198216NM_003091
RefSeq (protein): NP_003082NP_937859
Location (UCSC): Chr 20: 2.46 – 2.47 Mb

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.