Protein-coding gene in the species Homo sapiens

SMARCE1

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All data from the card 17

Aliases: SMARCE1, BAF57, CSS5, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
External IDs: OMIM: 603111; MGI: 1927347; GeneCards: SMARCE1
Chr.: Chromosome 17 (human)
Band: 17q21.2
End: 40,648,654 bp
Chr.: Chromosome 11 (mouse)
Band: 11|11 D
End: 99,121,843 bp
BioGPS: n/a
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 6605
Ensembl: ENSG00000073584
UniProt: Q969G3
RefSeq (mRNA): NM_003079
RefSeq (protein): NP_003070NP_003070.3
Location (UCSC): Chr 17: 40.62 – 40.65 Mb

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.

Function

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.