Protein-coding gene in the species Homo sapiens

RBBP7

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Aliases: RBBP7, RbAp46, retinoblastoma binding protein 7, RB binding protein 7, chromatin remodeling factor
External IDs: OMIM: 300825; MGI: 1194910; GeneCards: RBBP7
PDB: Ortholog search: PDBe RCSB
Chr.: X chromosome (human)
Band: Xp22.2
End: 16,870,362 bp
Chr.: X chromosome (mouse)
Band: X|X F4
End: 161,562,088 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 5931
Ensembl: ENSG00000102054
UniProt: Q16576
RefSeq (mRNA): NM_001198719NM_002893
RefSeq (protein): NP_001185648NP_002884
Location (UCSC): Chr X: 16.84 – 16.87 Mb

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Function

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.