Protein-coding gene in the species Homo sapiens

PRAM1

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Aliases: PRAM1, PML-RAR, PRAM-1, PML-RARA regulated adaptor molecule 1
External IDs: OMIM: 606466; MGI: 3576625; GeneCards: PRAM1
Chr.: Chromosome 19 (human)
Band: 19p13.2
End: 8,502,640 bp
Chr.: Chromosome 17 (mouse)
Band: 17|17 B1
End: 33,864,680 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 84106
Ensembl: ENSG00000133246
UniProt: Q96QH2
RefSeq (mRNA): NM_032152
RefSeq (protein): NP_115528
Location (UCSC): Chr 19: 8.49 – 8.5 Mb

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.

Function

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).