Protein-coding gene in the species Homo sapiens

OSBP2

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Aliases: OSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2
External IDs: OMIM: 606729; MGI: 1921559; GeneCards: OSBP2
Chr.: Chromosome 22 (human)
Band: 22q12.2
End: 30,907,824 bp
Chr.: Chromosome 11 (mouse)
Band: 11|11 A1
End: 3,813,903 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 23762
Ensembl: ENSG00000184792
UniProt: Q969R2
RefSeq (mRNA): NM_001003812NM_001282738NM_001282739NM_001282740NM_001282741NM_001282742NM_030758
RefSeq (protein): NP_001269667NP_001269668NP_001269669NP_001269670NP_001269671NP_110385
Location (UCSC): Chr 22: 30.69 – 30.91 Mb

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.

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OSBP2

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