Protein-coding gene in the species Homo sapiens

NME2

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Aliases: NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF, NME/NM23 nucleoside diphosphate kinase 2
External IDs: OMIM: 156491; MGI: 97356; GeneCards: NME2
PDB: Ortholog search: PDBe RCSB
2.7.4.6: ↗
2.7.13.3: ↗
Chr.: Chromosome 17 (human)
Band: 17q21.33
End: 51,171,744 bp
Chr.: Chromosome 11 (mouse)
Band: 11|11 D
End: 93,847,085 bp
BioGPS: n/a
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 4831
Ensembl: ENSG00000243678
UniProt: P22392
RefSeq (mRNA): NM_002512NM_001018137NM_001018138NM_001018139NM_001198682
RefSeq (protein): NP_001018147NP_001018148NP_001018149NP_001185611NP_002503NP_001018146
Location (UCSC): Chr 17: 51.17 – 51.17 Mb

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.

Function

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.