Protein-coding gene in the species Homo sapiens

MAP2K2

1 min read
In 4 languages

All data from the card 19

Aliases: MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDs: OMIM: 601263; MGI: 1346867; GeneCards: MAP2K2
PDB: Ortholog search: PDBe RCSB
2.7.12.2: ↗
Chr.: Chromosome 19 (human)
Band: 19p13.3
End: 4,124,122 bp
Chr.: Chromosome 10 (mouse)
Band: 10 C1|10 39.72 cM
End: 80,969,809 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 5605
Ensembl: ENSG00000126934
UniProt: P36507
RefSeq (mRNA): NM_030662
RefSeq (protein): NP_109587
Location (UCSC): Chr 19: 4.09 – 4.12 Mb

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.