Protein-coding gene in the species Homo sapiens

MAP1B

All data from the card 17

Aliases: MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDs: OMIM: 157129; MGI: 1306778; GeneCards: MAP1B
Chr.: Chromosome 5 (human)
Band: 5q13.2
End: 72,209,565 bp
Chr.: Chromosome 13 (mouse)
Band: 13 D1|13 52.9 cM
End: 99,653,048 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 4131
Ensembl: ENSG00000131711
UniProt: P46821
RefSeq (mRNA): NM_005909NM_032010NM_001324255
RefSeq (protein): NP_001311184NP_005900
Location (UCSC): Chr 5: 72.11 – 72.21 Mb

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

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