Mammalian protein found in Homo sapiens

Integrin alpha 4

1 min read
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All data from the card 18

Aliases: ITGA4, CD49D, IA4, integrin subunit alpha 4
External IDs: OMIM: 192975; MGI: 96603; GeneCards: ITGA4
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 2 (human)
Band: 2q31.3
End: 181,538,940 bp
Chr.: Chromosome 2 (mouse)
Band: 2 C3|2 47.38 cM
End: 79,163,467 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 3676
Ensembl: ENSG00000115232
UniProt: P13612
RefSeq (mRNA): NM_000885NM_001316312
RefSeq (protein): NP_000876NP_001303241
Location (UCSC): Chr 2: 181.46 – 181.54 Mb

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Function

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.