Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Mammalian protein found in Homo sapiens
Integrin alpha 2b
All data from the card 18
- Aliases
- ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
- External IDs
- OMIM: 607759; MGI: 96601; GeneCards: ITGA2B
- PDB
- Ortholog search: PDBe RCSB
- Chr.
- Chromosome 17 (human)
- Band
- 17q21.31
- End
- 44,389,649 bp
- Chr.
- Chromosome 11 (mouse)
- Band
- 11 D|11 66.29 cM
- End
- 102,360,948 bp
- BioGPS
- More reference expression data
- Databases
- NCBI: entry; OMA: entry
- Species
- Human
- Entrez
- 3674
- Ensembl
- ENSG00000005961
- UniProt
- P08514
- RefSeq (mRNA)
- NM_000419
- RefSeq (protein)
- NP_000410
- Location (UCSC)
- Chr 17: 44.37 – 44.39 Mb
Read next
Integrin beta 3Mammalian protein found in Homo sapiens
Glycoprotein IIb/IIIaIntegrin complex found on platelets
GP5 (gene)Protein-coding gene in the species Homo sapiens
Platelet membrane glycoproteinSurface glycoproteins involved in hemostasis
Integrin alpha 5Protein
GP1BBProtein-coding gene in the species Homo sapiensIn 7 languages
Text from Wikipedia, CC BY-SA 4.0 · Source article