Protein-coding gene in the species Homo sapiens

Intersectin 1

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All data from the card 18

Aliases: ITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
External IDs: OMIM: 602442; MGI: 1338069; GeneCards: ITSN1
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 21 (human)
Band: 21q22.11
End: 33,899,861 bp
Chr.: Chromosome 16 (mouse)
Band: 16|16 C4
End: 91,717,485 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 6453
Ensembl: ENSG00000205726
UniProt: Q15811Q6J334
RefSeq (mRNA): NM_001001132NM_003024NM_001331008NM_001331009NM_001331010NM_001331011NM_001331012
RefSeq (protein): NP_001001132NP_001317937NP_001317938NP_001317939NP_001317940NP_001317941NP_003015
Location (UCSC): Chr 21: 33.64 – 33.9 Mb

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.

Function

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.