Protein-coding gene in the species Homo sapiens

ING4

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All data from the card 18

Aliases: ING4, my036, p29inhibitor of growth family member 4
External IDs: OMIM: 608524; MGI: 107307; GeneCards: ING4
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 12 (human)
Band: 12p13.31
End: 6,663,142 bp
Chr.: Chromosome 6 (mouse)
Band: 6 F2|6 59.17 cM
End: 125,026,228 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 51147
Ensembl: ENSG00000111653
UniProt: Q9UNL4
RefSeq (mRNA): NM_001127582NM_001127583NM_001127584NM_001127585NM_001127586NM_016162NM_198287
RefSeq (protein): NP_001121054NP_001121055NP_001121056NP_001121057NP_001121058NP_057246
Location (UCSC): Chr 12: 6.65 – 6.66 Mb

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.

Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.