Human gene

IL3RA

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Aliases: IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs: OMIM: 308385, 430000; MGI: 96553; GeneCards: IL3RA
PDB: Ortholog search: PDBe RCSB
Chr.: X chromosome (human)
Band: X;Y
End: 1,382,689 bp
Chr.: Chromosome 14 (mouse)
Band: 14 A1|14 7.08 cM
End: 8,123,488 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 3563
Ensembl: ENSG00000185291
UniProt: P26951
RefSeq (mRNA): NM_001267713NM_002183
RefSeq (protein): NP_001254642NP_002174
Location (UCSC): Chr X: 1.34 – 1.38 Mb

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.

Function

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.