Protein-coding gene in the species Homo sapiens

GNB5

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Aliases: GNB5, guanine nucleotide binding protein (G protein), beta 5, GB5, G protein subunit beta 5, LADCI, IDDCA, gbeta5, HG2E
External IDs: OMIM: 604447; MGI: 101848; GeneCards: GNB5
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 15 (human)
Band: 15q21.2
End: 52,191,392 bp
Chr.: Chromosome 9 (mouse)
Band: 9 D|9 42.3 cM
End: 75,253,158 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 10681
Ensembl: ENSG00000069966
UniProt: O14775
RefSeq (mRNA): NM_006578NM_016194NM_001379343
RefSeq (protein): NP_006569NP_057278NP_001366272NP_006569.1
Location (UCSC): Chr 15: 52.12 – 52.19 Mb

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.