Protein-coding gene in humans

GIT2

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Aliases: GIT2, CAT-2, CAT2, PKL, GIT ArfGAP 2
External IDs: OMIM: 608564; MGI: 1347053; GeneCards: GIT2
Chr.: Chromosome 12 (human)
Band: 12q24.11
End: 109,996,389 bp
Chr.: Chromosome 5 (mouse)
Band: 5|5 F
End: 114,775,517 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 9815
Ensembl: ENSG00000139436
UniProt: Q14161
RefSeq (mRNA): NM_001135213NM_001135214NM_014776NM_057169NM_057170NM_139201NM_001330153NM_001330154
RefSeq (protein): NP_001128685NP_001128686NP_001317082NP_001317083NP_055591NP_476510NP_476511NP_631940
Location (UCSC): Chr 12: 109.93 – 110 Mb

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

Function

This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.