Protein-coding gene in the species Homo sapiens

EIF2B2

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Aliases: EIF2B2, EIF-2Bbeta, EIF2B, eukaryotic translation initiation factor 2B subunit beta, EIF2Bbeta
External IDs: OMIM: 606454; MGI: 2145118; GeneCards: EIF2B2
Chr.: Chromosome 14 (human)
Band: 14q24.3
End: 75,012,366 bp
Chr.: Chromosome 12 (mouse)
Band: 12|12 D1
End: 85,273,402 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 8892
Ensembl: ENSG00000119718
UniProt: P49770
RefSeq (mRNA): NM_014239
RefSeq (protein): NP_055054
Location (UCSC): Chr 14: 75 – 75.01 Mb

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.

Function

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.