Protein-coding gene in the species Homo sapiens

DOK5

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Aliases: DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs: OMIM: 608334; MGI: 1924079; GeneCards: DOK5
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 20 (human)
Band: 20q13.2
End: 54,651,169 bp
Chr.: Chromosome 2 (mouse)
Band: 2 H3|2 92.26 cM
End: 170,721,689 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 55816
Ensembl: ENSG00000101134
UniProt: Q9P104
RefSeq (mRNA): NM_001294161NM_018431NM_177959
RefSeq (protein): NP_001281090NP_060901NP_808874
Location (UCSC): Chr 20: 54.48 – 54.65 Mb

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.