Human protein and coding gene

DAB2

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Aliases: DAB2, DOC-2, DOC2, clathrin adaptor protein, DAB adaptor protein 2
External IDs: OMIM: 601236; MGI: 109175; GeneCards: DAB2
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 5 (human)
Band: 5p13.1
End: 39,462,300 bp
Chr.: Chromosome 15 (mouse)
Band: 15 A1|15 2.15 cM
End: 6,470,193 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 1601
Ensembl: ENSG00000153071
UniProt: P98082
RefSeq (mRNA): NM_001343NM_001244871
RefSeq (protein): NP_001231800NP_001334
Location (UCSC): Chr 5: 39.37 – 39.46 Mb

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

Function

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).