Protein-coding gene in humans

CPLX1

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Aliases: CPLX1, CPX-I, CPX1, complexin 1, EIEE63, DEE63
External IDs: OMIM: 605032; MGI: 104727; GeneCards: CPLX1
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 4 (human)
Band: 4p16.3
End: 826,129 bp
Chr.: Chromosome 5 (mouse)
Band: 5|5 F
End: 108,697,890 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 10815
Ensembl: ENSG00000168993
UniProt: O14810
RefSeq (mRNA): NM_006651
RefSeq (protein): NP_006642
Location (UCSC): Chr 4: 0.78 – 0.83 Mb

Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.

Function

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.