Protein-coding gene in the species Homo sapiens

CHMP3

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Aliases: CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDs: OMIM: 610052; MGI: 1913950; GeneCards: CHMP3
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 2 (human)
Band: 2p11.2
End: 86,563,479 bp
Chr.: Chromosome 6 (mouse)
Band: 6 C1|6 32.17 cM
End: 71,559,593 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 51652
Ensembl: ENSG00000115561
UniProt: Q9Y3E7
RefSeq (mRNA): NM_001005753NM_001193517NM_016079
RefSeq (protein): NP_001005753NP_001180446NP_057163
Location (UCSC): Chr 2: 86.5 – 86.56 Mb

Charged multivesicular body protein 3 is a protein that in humans is encoded by the CHMP3 gene (previously VPS24).

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.