Protein-coding gene in humans

CDC42EP2

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Aliases: CDC42EP2, BORG1, CEP2, CDC42 effector protein 2
External IDs: OMIM: 606132; MGI: 1929744; GeneCards: CDC42EP2
Chr.: Chromosome 11 (human)
Band: 11q13.1
End: 65,322,417 bp
Chr.: Chromosome 19 (mouse)
Band: 19 A|19 4.34 cM
End: 5,974,844 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 10435
Ensembl: ENSG00000149798
UniProt: O14613
RefSeq (mRNA): NM_006779
RefSeq (protein): NP_006770
Location (UCSC): Chr 11: 65.31 – 65.32 Mb

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

Function

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.