Protein-coding gene in humans

CDC34

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Aliases: CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDs: OMIM: 116948; MGI: 102657; GeneCards: CDC34
PDB: Ortholog search: PDBe RCSB
2.3.2.23: ↗
2.3.2.24: ↗
Chr.: Chromosome 19 (human)
Band: 19p13.3
End: 542,092 bp
Chr.: Chromosome 10 (mouse)
Band: 10 C1|10 39.72 cM
End: 79,524,232 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 997
Ensembl: ENSG00000099804
UniProt: P49427
RefSeq (mRNA): NM_004359
RefSeq (protein): NP_004350
Location (UCSC): Chr 19: 0.53 – 0.54 Mb

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.

CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle. Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1 - for ubiquitin-mediated protein degradation. CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.