Mammalian protein found in humans

CD7

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All data from the card 17

Aliases: CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDs: OMIM: 186820; MGI: 88344; GeneCards: CD7
Chr.: Chromosome 17 (human)
Band: 17q25.3
End: 82,317,608 bp
Chr.: Chromosome 11 (mouse)
Band: 11 E2|11 84.85 cM
End: 120,930,244 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 924
Ensembl: ENSG00000173762
UniProt: P09564
RefSeq (mRNA): NM_006137
RefSeq (protein): NP_006128
Location (UCSC): Chr 17: 82.31 – 82.32 Mb

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.

Function

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

Interactions

CD7 has been shown to interact with PIK3R1.

Clinical significance

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).