Protein-coding gene in the species Homo sapiens

APBA1

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Aliases: APBA1, D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA, amyloid beta precursor protein binding family A member 1
External IDs: OMIM: 602414; MGI: 1860297; GeneCards: APBA1
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 9 (human)
Band: 9q21.12
End: 69,672,371 bp
Chr.: Chromosome 19 (mouse)
Band: 19|19 B
End: 23,926,960 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 320
Ensembl: ENSG00000107282ENSG00000276497
UniProt: Q02410
RefSeq (mRNA): NM_001163
RefSeq (protein): NP_001154
Location (UCSC): Chr 9: 69.43 – 69.67 Mb

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.