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genyn codio-protien yn y rhywogaeth Homo sapiens

TDRD3

TDRD3
All data from the card 12
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
TDRD3, tudor domain containing 3
Dynodwyr allanol
OMIM: 614392 HomoloGene: 12771 GeneCards: TDRD3
Gweithrediad moleciwlaidd
• methylated histone binding• GO:0001105 transcription coactivator activity• chromatin binding• GO:0001948, GO:0016582 protein binding• RNA binding
Cydrannau o'r gell
• cytoplasm• exon-exon junction complex• cnewyllyn cell• nucleoplasm• Golgi apparatus• cytosol
Species
Bod dynol
Entrez
81550
Ensembl
ENSG00000083544
UniProt
Q9H7E2
RefSeq (mRNA)
NM_001146070NM_001146071NM_030794
RefSeq (protein)
NP_001139542NP_001139543NP_110421
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn TDRD3 yw TDRD3 a elwir hefyd yn Tudor domain containing 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q21.2.

Llyfryddiaeth

  • "Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. ". Hum Mol Genet. 2008. PMID 18664458.
  • "TDRD3 is an effector molecule for arginine-methylated histone marks. ". Mol Cell. 2010. PMID 21172665.
  • "RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. ". Nucleic Acids Res. 2016. PMID 27257063.
  • "Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells. ". Cell Discov. 2017. PMID 28101374.
  • "Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.". PLoS One. 2012. PMID 22363433.

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