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SMURF2

SMURF2
All data from the card 12
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
SMURF2, SMAD specific E3 ubiquitin protein ligase 2
Dynodwyr allanol
OMIM: 605532 HomoloGene: 41490 GeneCards: SMURF2
EC number
2.3.2.26
Cydrannau o'r gell
• cytosol• bilen• ubiquitin ligase complex• cellbilen• nucleoplasm• membrane raft• nuclear speck• cnewyllyn cell• cytoplasm
Species
Bod dynol
Entrez
64750
Ensembl
ENSG00000108854
UniProt
Q9HAU4
RefSeq (mRNA)
NM_022739
RefSeq (protein)
NP_073576
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMURF2 yw SMURF2 a elwir hefyd yn SMAD specific E3 ubiquitin protein ligase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q23.3-q24.1.

Llyfryddiaeth

  • "Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. ". Cancer Res. 2009. PMID 19155312.
  • "Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication. ". Am J Physiol Renal Physiol. 2008. PMID 18353873.
  • "Ectopic expression of Smurf2 and acceleration of age-related intervertebral disc degeneration in a mouse model. ". J Neurosurg Spine. 2017. PMID 28387615.
  • "Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma. ". J Natl Cancer Inst. 2013. PMID 23250956.
  • "Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.". Neuropathol Appl Neurobiol. 2011. PMID 20819168.

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