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RB1

RB1
All data from the card 11
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
RB1, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1
Dynodwyr allanol
OMIM: 614041 HomoloGene: 272 GeneCards: RB1
Cydrannau o'r gell
• PML body• SWI/SNF complex• transcription regulator complex• spindle• cyclin/CDK positive transcription elongation factor complex• chromatin• cnewyllyn cell• nucleoplasm• Rb-E2F complex
Species
Bod dynol
Entrez
5925
Ensembl
ENSG00000139687
UniProt
P06400
RefSeq (mRNA)
NM_000321
RefSeq (protein)
NP_000312NP_000312.2
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn RB1 yw RB1 a elwir hefyd yn RB transcriptional corepressor 1 a Retinoblastoma 1 (Including osteosarcoma), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q14.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RB1.

  • RB
  • pRb
  • OSRC
  • pp110
  • p105-Rb
  • PPP1R130

Llyfryddiaeth

  • "Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. ". Biomed Res Int. 2016. PMID 28101510.
  • "Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids. ". Development. 2017. PMID 28087635.
  • "Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation. ". Cancer Sci. 2017. PMID 28865172.
  • "Defective splicing of the RB1 transcript is the dominant cause of retinoblastomas. ". Hum Genet. 2017. PMID 28780672.
  • "Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling.". PLoS One. 2017. PMID 28575107.

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Text from Wikipedia, CC BY-SA 4.0 · Source article