factograf
CY

genyn codio-protien yn y rhywogaeth Homo sapiens

FRS2

FRS2
All data from the card 11
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
FRS2, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A, fibroblast growth factor receptor substrate 2
Dynodwyr allanol
OMIM: 607743 HomoloGene: 4846 GeneCards: FRS2
Cydrannau o'r gell
• cytoplasm• endosome• bilen• cellbilen• integral component of plasma membrane• endomembrane system• cell-cell junction• cytosol
Species
Bod dynol
Entrez
10818
Ensembl
ENSG00000166225
UniProt
Q8WU20
RefSeq (mRNA)
NM_006654NM_001042555NM_001278351NM_001278353NM_001278354NM_001278355NM_001278356NM_001278357
RefSeq (protein)
NP_001036020NP_001265280NP_001265282NP_001265283NP_001265284NP_001265285NP_001265286NP_006645
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn FRS2 yw FRS2 a elwir hefyd yn Fibroblast growth factor receptor substrate 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FRS2.

  • SNT
  • SNT1
  • FRS1A
  • FRS2A
  • SNT-1
  • FRS2alpha

Llyfryddiaeth

  • "FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. ". Cell Res. 2009. PMID 19652666.
  • "EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. ". Biol Chem. 2003. PMID 12974390.
  • "Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. ". Oncogene. 2016. PMID 26096936.
  • "The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. ". Mol Cancer Res. 2015. PMID 25368431.
  • "High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.". Genes Chromosomes Cancer. 2011. PMID 21793095.

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