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genyn codio-protien yn y rhywogaeth Homo sapiens

BID

BID
All data from the card 12
PDB
Human UniProt search: PDBe RCSB
Cyfenwau
BID, Bid, 2700049M22Rik, AI875481, AU022477, FP497, BH3 interacting domain death agonist
Dynodwyr allanol
OMIM: 601997 HomoloGene: 923 GeneCards: BID
Gweithrediad moleciwlaidd
• death receptor binding• GO:0001948, GO:0016582 protein binding• ubiquitin protein ligase binding• protein heterodimerization activity
Cydrannau o'r gell
• cytoplasm• bilen• mitochondrial membranes• mitochondrial outer membrane• mitocondria• integral component of mitochondrial membrane• cytosol
Species
Bod dynol
Entrez
637
Ensembl
ENSG00000015475
UniProt
P55957
RefSeq (mRNA)
NM_001196NM_001244567NM_001244569NM_001244570NM_001244572NM_197966NM_197967
RefSeq (protein)
NP_001187NP_001231496NP_001231498NP_001231499NP_001231501NP_932070NP_932071NP_001187.1NP_001231496.1
Lleoliad (UCSC)
n/a

Protein sy'n cael ei godio yn y corff dynol gan y genyn BID yw BID a elwir hefyd yn BH3 interacting domain death agonist, isoform CRA_d a BH3 interacting domain death agonist (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BID.

  • FP497

Llyfryddiaeth

  • "Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. ". J Biol Chem. 2016. PMID 27053107.
  • "Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. ". Apoptosis. 2016. PMID 26758067.
  • "Adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells. ". Oncol Rep. 2017. PMID 27878291.
  • "Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis. ". Cell Death Dis. 2016. PMID 27763642.
  • "A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.". Cancer Lett. 2016. PMID 27461583.

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