Parkinson's disease (PD), anaa simply Parkinson's, be a neurodegenerative disease primarily of de central nervous system, wey dey affect both motor den non-motor systems. Symptoms typically dey develop gradually, plus non-motor issues wey cam turn more prevalent as de disease dey progress. De motor symptoms be collectively called parkinsonism den dey include tremors, bradykinesia, rigidity as well as postural instability (i.e., difficulty maintaining balance). Non-motor symptoms dey develop later insyd de disease den dey include behavioral changes anaa neuropsychiatric problems such as sleep abnormalities, psychosis, den mood swings.
Chaw Parkinson's disease cases be sporadic, though dem identify factors wey dey contribute. Pathophysiology dey involve progressive degeneration of nerve cells insyd de substantia nigra, a midbrain region wey dey provide dopamine to de basal ganglia, a system wey involve insyd voluntary motor control. De cause of dis cell death be poorly understood buh e dey involve de aggregation of alpha-synuclein into Lewy bodies within neurons. Oda potential factors dey involve genetic den environmental influences, medications, lifestyle, den prior health conditions.
Diagnosis primarily dey base for signs and symptoms top, typically motor-related, identified thru neurological examination. Medical imaging techniques like positron emission tomography fi support de diagnosis. Parkinson's typically dey manifest insyd individuals over 60, plus about one percent wey be affect. Insyd those younger dan 50, e be termed "early-onset PD".
