Protein-coding gene in the species Homo sapiens

CYTH1

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Aliases: CYTH1, B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7, cytohesin 1
External IDs: OMIM: 182115; MGI: 1334257; GeneCards: CYTH1
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 17 (human)
Band: 17q25.3
End: 78,782,297 bp
Chr.: Chromosome 11 (mouse)
Band: 11|11 E2
End: 118,139,418 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 9267
Ensembl: ENSG00000108669
UniProt: Q15438
RefSeq (mRNA): NM_001292018NM_001292019NM_004762NM_017456NM_001365037NM_001365038NM_001365039NM_001365040NM_001365041NM_001394676NM_001394677NM_001394678
RefSeq (protein): NP_001278947NP_001278948NP_004753NP_059430NP_001351966NP_001351967NP_001351968NP_001351969NP_001351970
Location (UCSC): Chr 17: 78.67 – 78.78 Mb

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

Function

Cytohesin-1 (CYTH1) is a member of the cytohesin family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The CYTH1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. CYTH1 protein is 83% homologous to CYTH2.