Protein found in humans

Afadin

1 min read
In 3 languages

All data from the card 18

Aliases: AFDN, AF6, MLL-AF6, MLLT4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4, afadin, adherens junction formation factor, l-afadin
External IDs: OMIM: 159559; MGI: 1314653; GeneCards: AFDN
PDB: Ortholog search: PDBe RCSB
Chr.: Chromosome 6 (human)
Band: 6q27
End: 167,972,023 bp
Chr.: Chromosome 17 (mouse)
Band: 17|17 A1- A2
End: 14,126,412 bp
BioGPS: More reference expression data
Databases: NCBI: entry; OMA: entry
Species: Human
Entrez: 4301
Ensembl: ENSG00000130396
UniProt: P55196
RefSeq (mRNA): NM_001040000NM_001040001NM_001207008NM_001291964NM_005936NM_001366319NM_001366320NM_001366321NM_001386888
RefSeq (protein): NP_001035089NP_001193937NP_001278893NP_001353248NP_001353249NP_001353250
Location (UCSC): Chr 6: 167.83 – 167.97 Mb

Afadin is a protein that in humans is encoded by the AFDN gene.

Function

Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM]